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2.1.6.3. Folate: Folic acid (500 microg/d) supplementation was initiated at 2.5 g/d of folic acid (Vitamin B9). (500 microg/d) was increased in the placebo group to 3 g/d throughout the trial. Folic acid was continued in the active treatment group through third trimester with a second dose at delivery. Folic acid is the water-soluble part of B-vitamin complex. Folic acid has been recognized as essential to fetal and infant development has also been identified as a cofactor for folate metabolism. The bioavailability of is increased by dietary intake. Th
